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Aim and Background: The coronavirus disease 2019 (Covid-19) virus pandemic is still ravaging the world with its ongoing resurgence and the continuous mutation, suggesting the need for continuous research on safe and effective novel vaccines. Presently several types of vaccines have been developed and emerged in the global market to control COVID-19 virus. Consequently, the knowledge and information on COVID-19 have been expanding at a high level. Researchers need to gain relevant knowledge regarding the different vaccines;however scattered information makes this process time-consuming and laborious. The present study aimed to evaluate the characteristics and trends in global COVID-19 vaccine high-cited literature using bibliometric and visualizations methods and offer some directions and suggestions for future research. Methodology: Studies published between December 2019 and 22 Nov 2022 on COVID-19 vaccines were retrieved from the Scopus database. From the 16026 studies retrieved, 406 were identified as high-cited papers (HCPs) having received 100 or more citations. From the 406 HCPs, information about publications outputs, countries, institutions, journals, keywords, and citation counts was identified. Data analysis and visualization were conducted using Microsoft Excel, VOSviewer and Bibliometrix R software. Result(s): The 406 global HCPs on COVID-19 vaccines research were identified in Scopus database since Dec 2019 till 30 Nov 2022 using a search strategy, which received 123614 citations, averaging 304.17 citations per publication (CPP). An external funding was received by 53.20% (216 publications), which were cited 76107 times (with an average of 352.35 CPP). The 7086 authors from 694 organizations affiliated to 76 countries and publishing in 121 journals were involved in global COVID-19 vaccine research. The most productive countries were USA (n=213), U.K (n=91), China (n=36) and Germany (n=35). The most impactful countries in terms of citations per paper (CPP) and relative citation index (RCI) were South Africa (794.68 and 2.61), Germany (507.11 and 1.67), U.K. (396.59 and 1.30) and Spain (367.5 and 1.121). The most productive organizations were University of Oxford, U.K., Imperial College London, U.K. (n=25 each), Center for Disease Control and Prevention (CDC), USA and Tel Aviv University (n=19 each) and the most impactful organizations were University of Cambridge, U.K (783.4 and 2.57), Emory University, USA (780.1 and 2.56), John Hopkins Bloomberg School of Public Health, USA (702.67 and 2.31) and National Institute of Allergy and Infectious Diseases. USA (676.41 and 2.22). The most productive authors were A.J. Pollard (n=16) and T. Lambe (n=14) (of University of Oxford), O. Tureci and P.R. Dormitzer (n=12 each) (of BioNTechSE, Germany) and the most impactful were D. Cooper (1239.22 and 4.07), K.J. Janseu (1228.11 and 4.03) (BioNTechSE, Germany, K.A. Swanson (987.0 and 3.24) (University of Oxford, U.K.) and P.R. Dormitzer (983 and 3.23) (BioNTechSE, Germany). The most productive journals were New England Journal of Medicine (n=53), The Lancet (n=28), Nature (n=22) and JAMA (N=17). The most impactful journals (as per citations per paper) were New England Journal of Medicine (613.15), Lancet (496.39), Human Vaccines and Immunotherapeutics (369.67) and Nature (360.64). Among population age groups, the major focus was on adults (51.48%) and Middle Aged (39.16%). Among publication types, the major focus was Clinical Studies (26.85%), Epidemiology (22.66%) and Genetics (21.92%). The most significant keywords by frequency of appearances were "Covid-19" (n=388), "Covid-19 Vaccines" (n=357), "Vaccination" (n=221), "Prevention and Control" (n=181) and "Vaccine Immunogenicity" (n=133), Conclusion(s): The HCPs in COVID-19 vaccine research was done mainly by the authors and institutions of high-income Countries (HIC) and was published in high-impact medical journals. Our research has identified the leading countries, institutions, journals, hotspots and development trend in the field that could provide the foundati n for further investigations. The bibliometric analysis will help the clinicians to rapidly identify the potential collaborative partners, identify significant studies, and research topics within their domains of COVID-19 vaccines.Copyright Author (s) 2023.
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Background: The present radiological COVID literature is mainly confined to the CT findings. Using High Resolution Computed tomography (HRCT) as a regular 1st line investigation put a large burden on radiology department and constitute a huge challenge for the infection control in CT suite. Materials and Methods: A prospective study of 700 consecutive COVID positive cases who underwent Chest Xray (CXR) and HRCT thorax were included in the study. Many of these CXR were repeated and followed up over a duration of time to see the progression of disease. Results: 392/700 (56%) were found to be negative for radiological thoracic involvement. 147/700 (21%) COVID positive patients showed lung consolidations, 115/700 (16.5%) presented with GGO, 40/700 (5.7%) with nodules and 42/700 (6%) with reticular–nodular opacities. 150/700 patients (21.4 %) had mild findings with total RALE severity score of 1-2. More extensive involvement was seen in 104/700 (14.8 %) and 43/700 (6.2%) patients, who had severity scores of 3-4 and 5-6 respectively. 11/700 patients had a severity score of >6 on their baseline CXR. Those with severity score of 5 or more than 5 (54/700, 7.7%) required aggressive treatment with mean duration of stay of 14 days, many of them died also (23/54, 42.5%). Conclusion: In cases of high clinical suspicion for COVID-19, a positive CXR may obviate the need for CT. Additionally, CXR utilization for early disease detection and followup may also play a vital role in areas around the world with limited access to CT and RT-PCR test.
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Background: Corona virus emerged in China in December 2019 and quickly spread over the world, causing a pandemic. The probable link between the occurrence of neurological abnormalities and the CT severity score (CTSS) in COVID-19 participants is less understood. The purpose of this study was to look at the neurological symptoms of COVID-19 on CT head and determine whether there was a link between thorax and brain imaging abnormalities in COVID-19 patients. Method(s): Total 135 Hospitalized COVID positive patients with acute neurological symptoms underwent both CT head and CT thorax during their hospital stay were included in the study. All the patients with neuroimaging were divided into 2 groups: first being patients with acute neuroimaging findings and the second being the patients with chronic/normal neuroimaging findings. Result(s): The most common CT head imaging findings in these individuals were acute ischemic infarcts in 54 (40%) and acute intracranial haemorrhage in 8 (6%). When compared to individuals with normal/chronic neurological results, a greater mean chest CTSS was found in patients with acute abnormalities on CT head (14.1 [SD-3.2] versus 6.5 [SD-3.3]). However, no statistical correlation could be shown between a greater CTSS and the occurrence of acute neurological disorders. Conclusion(s): There was no link between a greater CTSS and the occurrence of neurological disorders on CT scans. As a result, increased lung involvement severity may not be a good predictor of brain involvement in COVID patients. Copyright © 2022 Ubiquity Press. All rights reserved.
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Background: The present radiological COVID literature is mainly confined to the CT findings. Using High Resolution Computed tomography (HRCT) as a regular 1st line investigation put a large burden on radiology department and constitute a huge challenge for the infection control in CT suite. Material(s) and Method(s): A prospective study of 700 consecutive COVID positive cases who underwent Chest Xray (CXR) and HRCT thorax were included in the study. Many of these CXR were repeated and followed up over a duration of time to see the progression of disease. Result(s): 392/700 (56%) were found to be negative for radiological thoracic involvement. 147/700 (21%) COVID positive patients showed lung consolidations, 115/700 (16.5%) presented with GGO, 40/700 (5.7%) with nodules and 42/700 (6%) with reticular-nodular opacities. 150/700 patients (21.4 %) had mild findings with total RALE severity score of 1-2. More extensive involvement was seen in 104/700 (14.8 %) and 43/700 (6.2%) patients, who had severity scores of 3-4 and 5-6 respectively. 11/700 patients had a severity score of >6 on their baseline CXR. Those with severity score of 5 or more than 5 (54/700, 7.7%) required aggressive treatment with mean duration of stay of 14 days, many of them died also (23/54, 42.5%). Conclusion(s): In cases of high clinical suspicion for COVID-19, a positive CXR may obviate the need for CT. Additionally, CXR utilization for early disease detection and followup may also play a vital role in areas around the world with limited access to CT and RT-PCR test. Copyright © 2022, Dr Yashwant Research Labs Pvt Ltd. All rights reserved.
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Background: Many patients with Covid-19 have underlying cardiovascular disease or develop acute cardiac injury during the course of the illness. Adequate understanding of the interplay between Covid-19 and Cardiovascular disease is required for optimum management of these patients. The study analyzed and evaluated the global publication output on "Covid-19 and Heart Diseases" to find out the current trends and present status of research, by identifing important countries, organizations, authors and journals and important topics and keywords from the global publications, using bibliometric methods. Methods: Relevant published literature from December 2019 to August 2021 were identified and analyzed on the topic "Covid-19 and Heart Diseases" using a well-defined search strategy in Scopus database. A list of keywords were identified for Covid-19 ("Covid 19" or "2019 novel Coronavirus" or "Coronavirus 2019" or "Coronavirus disease 2019" or "2019-novel CoV" OR "2019 ncov" or "Covid 2019" or "Covid19" or "Corona virus 2019" or "ncov-2019" or "ncov2019" or "nCoV 2019" or "2019-ncov" or "covid-19" or "Severe acute respiratory syndrome coronavirus 2" or "SARS-CoV-2") and Heart Diseases (cardi* or arrhythmia or myocardial* or heart*) and these keywords are used for search in "Keywords" and Title" tags of Scopus database, yielding 5298 records. Results: A total of 5298 relevant publications indexed in Scopus database were obtained on "Covid-19 and Heart Disease", which received 62459 citations, averaging 11.79 citations per paper. The total publications witnessed the participation of 123 countries, with USA, Italy, U.K. and China leading in global publication productivity (with 1757, 707, 551 and 413 papers) and China (35.31 and 2.99), France (23.01 and 1.95), Germany (23.0 and 1.95) and Italy (20.43 and 1.73) leading in citation impact per publication and relative citation index. The 1761 organizations and 2499 authors participated in these 5298 publications. Harvard Medical School, USA, Brigham and Women's Hospital, USA and Massachsetts General Hospital leads in publications productivity (with 178, 92 and 92 publications each) and New York Presbyterian Hospital, USA (121.53 and 10.31), Tongji Medical College, China (65.65 and 5.57) and Huazhong University of Science and Technology, China (65.41 and 5.55) leads in citations impact per paper and relative citation index. M. Metra, A. Harky and M.K. Chung leads in publications productivity (with 23, 22 and 153 papers each) and G.Y.H. Lip (U.K.)(114.67 and 9.73), A.J. Kirtane (USA)(109.67 and 9.3) and M. Metra (Italy)(87.04 and 7.38) leads in citations impact per publication and relative citation index. European Heart Journal, Circulation and Stroke leads in publication productivity (with 85, 81 and 73 publications) and JAMA Cardiology (154.23), Journal of the American College of Cardiology (54.99) and Circulation (43.54) leads in citation impact per paper. Major keywords appearing along with "Covid-19 and "Heart Diseases" in co-occurnces were "Cardiovascular Disease" (1176), "Heart Failure" (802), "Hypertension" (664), "Cerebrovascular Accidents" (659), "Stroke" (608), "Mycarditis" (511), "Heart Arrhytthrmia"(464), etc. Conclusion: The study presents the current trends and status of research in the field and indicate the important keywords where research is focused in global literature on cardiovascular manifestations in Covid-19 patients. Such a analysis tmay be useful to the research community and decision-makers to prioritize research needs and identify leading Covid-19 researchers, countries, institutes and authors.
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Background: The study analyzed and evaluated the scientific research on "Covid-19 and Aged People" to find out the current status of research and to identify significant players (countries, organizations and authors) and important topics from the 469 high-cited publications receiving 100 and more citations using bibliometric methods. Methods: High-cited publications published from December 2019 to June 2021 were identified and analyzed. A list keywords were identified for Covid-19 ("Covid 19" or "2019 novel Coronavirus" or "Coronavirus 2019" or "Coronavirus disease 2019" or "2019-novel CoV" OR "2019 ncov" or "Covid 2019" or "Covid-19" or "Corona virus 2019" or "ncov-2019" or "ncov2019" or "nCoV 2019" or "2019-ncov" or "covid-19" or "Severe acute respiratory syndrome coronavirus 2" or "SARS-CoV-2") and Aged People ("Aged" or "Elderly" or "Old" or "Very Elderly") and these keywords are used for search on the topic of study (the title, , keywords). Results: A total of 469 high-cited publications were obtained on this topic, which registered 449.5 citations per paper and witnessed the participation of 64 countries, with China, USA and U.K. leading in global publication productivity (with 189, 162 and 70 publications each) and China (687.25), Singapore (409.20) and Switzerland (396.41) leading in citation impact per paper. The 2123 organizations and 5896 authors participated in these 469 high-cited publications. Huazong University of Science and Technology, China, Wuhan University, China and University of Oxford, U.K. leads in publications productivity (with 66, 37 and 20 publications each) and Capital Medical University, China, University of Hong Kong (1454.6) and Shanghai Jiao Tong University, China leads in citations impact per paper. L. Liu, J. Chen and Y. Hu leads in publications productivity (with 16, 13 and 13 publications each) and Y. Liu (17100.5), Y.Hu (15395.5) and L. Zhang (15079.0) leads in citations impact per paper. New England Journal of Medicine, Lancet and JAMA - Journal of the American Medical Association leads in both publication productivity and citations impact per paper. The keywords that appeared most were "Covid-19" and "Aged People" which had a strong links with "mortality", "hospitalization", "hypertension", "respiratory failure", "diabetes mellitus", "chronic kidney failure", "anxiety:, "depression" and "mental health". Conclusion: The current bibliometric analysis provides information about the quantity and quality of research in this area based on published literature. It provides information on current status of research in this area to decision-makers and practicing scholars and provides important clues about upcoming research topics for future research.
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Background: Covid-19 pandemic had been a disastrous catastrophe on human race affecting different groups of population differently. Pregnancy is a condition which too has been affected by Covid-19. The present study aims to examine the research productivity of Covid-19 and pregnancy. Methods: Keywords pertaining to “Covid-19” and “Pregnancy” were used in search string in Scopus database for the period 2020-21. Data regarding publications growth, productive countries, authors and institutions, high cited papers and significant keywords was retrieved to analyze results. Results: The search retrieved 2945 global publications for the period 2020-21. The USA, UK and China were the most productive countries (with 28.96%, 11.27% and 9.3% global share) on “Covid-19 and Pregnancy”. The 613 organizations and 953 authors participated in global research on the subject, with top 20 most productive organizations and authors contributing 26.38% and 9.68% global publication share and 53.64% and 38.53% global citation share respectively. Huazhong University of Science and Technology, China, Tongji Medical College, China and Harvard Medical School, USA were the most productive organizations (with 68, 64 and 52 publications) and Huazhong University of Science and Technology, China (45.88 and 2.12), Tongji Medical College, China (44.96 and 2.08) and University of Health Sciences, Turkey (22.38 and 1.03) led the world as most impactful organizations in terms of citation impact and relative citation index. A Khalil (23 papers), C. Gyamfi-Bannerman (19 papers) and D. Goffman and I.C. Poon (17 papers each) were the most productive authors and H. Yang (197.4 and 4.66), l. Feng (105.12 and 2.5) and D.A. Schwartz (74.82 and 1.77) were the most impactful authors. American Journal of Obstetrics and Gynecology (94 papers), International Journal of Obstetrics and Gynecology (85 papers) and European Journal of Obstetrics and Gynecology and Reproductive Biology (66 papers) were the most productive journals in global research on “Covid-19 and Pregnancy”. JAMA-Journal of the American Medical Association (45.52), Acta Obstetricia et Gynecologica Scandinavica (34.22) and Ultrasound in Obstetrics and Gynecology (25.95) were leading most impactful journals. The 61 (2.07%) out of 2945 global publications on “Covid-19 and Pregnancy” registered 102 to 1571 citations per paper and they together received 14620 citations averaging 239.67 citations per paper. These 61 publications are assumed as high cited publications and involve 153 authors, 116 organizations and published in 43 journals.